Without insulin, the body is unable to process glucose effectively which is essential for survival.
Evidence of autoimmune is provided by the appearance of autoantibodies prior to the onset of clinical disease.
The etiology of Type I diabetes is multifactorial. The extremely wide geographic and racial variability in both the incidence and prevalence of Type I diabetes mellitus suggests that genetic plays a significant role in the etiology of the disease.
Risk factors for type I diabetes include genetic propensity and family history, environmental and/or dietary factors or triggers, ethnoracial distribution, and geography.
The environmental modifiers of disease onset can vary from agents such as viruses proposed to precipitate diabetes onset to those inhibiting diabetes onset in susceptible individuals.
Complications of diabetes such as cardiovascular disease, diabetic retinopathy and nephropathy can develop in affected individuals.
Chronic disease of Type 1 diabetes
