Tuesday, May 29, 2018

Vitamin D deficiency inhibits the pancreatic secretion of insulin

Based on basic and animal studies, vitamin D and calcium have also been suspected as modifiers of diabetes risk. Vitamin D insufficiency has long been suspected as a risk factor for type 1 diabetes based on animal and human observational studies (Mathieu C, Badenhoop K 2005 Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab 16:261–266).

More recently, there is accumulating evidence to suggest that altered vitamin D and calcium homeostasis may also play a role in the development of type 2 Diabetes Mellitus.

Animal and in vitro studies provide compelling evidence that vitamin D may play a functional role in the preservation of glucose tolerance through its effects on insulin secretion and insulin sensitivity.
Vitamin D deficient rabbits and mice present with impaired insulin secretion, and supplementation with vitamin D corrects the defect [C. Cade and A. W. Norman, “Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo,” Endocrinology, vol. 119, no. 1, pp. 84–90, 1986].

Vitamin D deficiency may influence its effects on insulin secretion and sensitivity via its effects on intracellular calcium [A. G. Pittas, J. Lau, F. B. Hu, and B. Dawson-Hughes, “The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 6, pp. 2017–2029, 2007].

Elevated intracellular calcium impairs post-receptor binding insulin action, such as the dephosphorylation of glycogen synthase and of insulin regulatable glucose transporter (GLUT-4). Vitamin D deficiency results in elevated parathyroid hormone (PTH), which in turn is known to elevate intracellular calcium.
Vitamin D deficiency inhibits the pancreatic secretion of insulin
Related Posts Plugin for WordPress, Blogger...

Popular Posts

Other Interesting Articles

  • The precursor of the H5N1 influenza virus that spread to humans in 1997 was first detected in China of Guangdong province, in 1996, when it caused a modera...
  • Arsenic is an element that raises much concern from the both environmental and human health standpoints. Arsenic is one of the most toxic metals derived fr...
  • Mining may well have been the second of humankind’s earliest endeavors —granted that agriculture was the first. Primary diamond deposits have been mined on...