The lipid changes associated with diabetes mellitus are attributed to increased free fatty acid flux secondary to insulin resistance. The changes represent the major link between diabetes and the increased cardiovascular risk of diabetic patients.
Diabetic dyslipidemia is extremely common in type 2 diabetes (T2DM) affecting around 70 % of patients. Diabetic is a significant risk factor for atherosclerotic cardiovascular disease (ASCVD) which is the most common cause of death in the United States.
Several factors are likely to be responsible for diabetic dyslipidemia:
*Insulin effects on liver apoprotein production,
*Regulation of lipoprotein lipase (LpL),
*Actions of cholesteryl ester transfer protein (CETP), and
*Peripheral actions of insulin on adipose and muscle.
Dyslipidemia is common in diabetes. There is an association between atherosclerotic cardiovascular disease and serum cholesterol and triglyceride levels in both type 1 and type 2 diabetes.
Diabetic dyslipidemia
