Friday, October 30, 2020

AVP (arginine vasopressin)

AVP or arginine vasopressin, sometimes also called anti-diuretic hormone or ADH, or argipressin or vasopressin is a hormone synthesized as a peptide pro-hormone in magnocellular neurons in the hypothalamus, and is converted to AVP.

AVP is a small nine-amino-acid peptide secreted by the neuro-hypophysis in response to minor increases in plasma osmolality or to comparatively larger reductions in blood volume. There is growing evidence that supports a role of AVP in regulation of blood glucose concentration.

AVP is short-lived in plasma, with a mean half-life of 24 minutes, and this hormone plays a major role in water conservation by increasing the permeability of the collecting duct to water and stimulating urea movements in the kidney which promote more intense water reabsorption in the renal medulla.

Researchers discovered that diabetic rats, in contrast to control rats, have increased hypothalamic vasopressin synthesis due to upregulated chloride transporters and an excitatory response evoked by the neurotransmitter GABA. These findings thus reveal a potential mechanistic explanation for elevated vasopressin concentration in diabetes.

Plasma vasopressin levels are elevated in uncontrolled diabetes mellitus. Furthermore, experimental studies demonstrated increased AVP synthesis, which was thought to be a compensatory response to the elevated AVP secretion.
AVP (arginine vasopressin)

Popular Posts

Other Interesting Articles

  • The main minerals that keep human health intact and prevent from getting ill with a wide range of diseases are: Calcium, Magnesium, Potassium and Iron. The...
  • *Rosmarinus officinalis*, L. originating from the Mediterranean region is an aromatic plant from the Lamiaceae family. Rosemary plants have been used in f...
  • Blondie is categorized as 'cookie bars'. Its texture is softer than cookies, but tougher than a cake. Blondies are sweet, chewy and melt in mouth. Blondi...